Wogonin, morin, chrysin, eudesmin, mandolin and honokiol inhibit TNF-α through regulation of JAK/STAT3 (Janus kinase/signal transducer and activators of transcription) pathway or PI3K/Akt/MAPKs-NF-κB pathways, suggesting them to be possible candidates against AD pathology. The gene discussed is NFKB1; the disease is Alzheimer disease.