TNFRSF1B and myeloid sarcoma: When TNF-α binds to TNFR2, it can activate CXC motif chemokine 12 (CXCL12)/CXC chemokine receptor type 4 (CXCR4), responsible for the proliferation, differentiation, and re-myelination of the demyelinated neurons in MS lesions [14].