MicroRNA‐30a plays an important role in the development of various disease.3 Roderburg discovered that miR‐30 family members were abundantly expressed in adult liver tissue and significantly down‐regulated in the process of liver fibrosis.11 In this study, we found miR‐30a was involved in regulation expression of FAP‐α, col1a and α‐SMA induced by TGF‐β1 and also promoted the proliferation of MRC5 cells, whereas FAP‐α was a direct target of miR‐30a. The gene discussed is TGFB1; the disease is Hepatic fibrosis.