At week 10‐11, the decrease in circulating and placental levels of PROK1 possibly contributes to differentiation and invasion of extravillous trophoblasts into the decidua and remodelling the maternal spiral arteries to ensure sufficient amount of oxygen and nutrients for the growing foetus.2 Dysregulation of PROK1 has been associated with placenta‐related pregnancy complications, such as pre‐eclampsia and intrauterine growth restriction.2, 3, 4. Here, PROK1 is linked to fetal growth restriction.