Indeed, a recent prospective study on childhood asthma showed a correlation between low IL‐2 responses early in life and elevated total IgE levels and allergic rhinitis later on.26 This highlights the importance of sufficient IL‐2 levels to support peripheral tolerance induction.12 However, individuals suffering, for example, from perennial allergies would have to undergo IL‐2/αIL‐2 complex‐based Treg expansion in the constant presence of allergen exposure. The gene discussed is IL2; the disease is allergic rhinitis.