We took advantage of a recently established humanized allergy model, which is specific for mugwort allergy and based on the co‐expression of a human TCR and HLA‐DR1.4 Mice were exposed to IL‐2/αIL‐2 complexes 23 in the presence or absence of mugwort pollen extract (MPE, days 0‐2), while control mice were exposed to MPE or PBS alone. The gene discussed is IL2; the disease is Allergy.