Several studies have demonstrated that MM cell (either cell lines or primary cells) upregulate PD‐L1, and its receptor PD‐1 is found on a proportion of T cells.13, 14, 15, 16 Moreover, dendritic cells (DC) in MM bone marrow expressed PD‐L1 and induced a suppression of PD‐1‐expressing T‐cell and NK‐cell immune functions by engaging immune checkpoints via the PD‐L1/PD‐1 signaling axis.17 Herein, we aimed to assess the immunomodulatory effects of Dara on CD38 expressing immune cells in the blood of newly diagnosed MM patients receiving Dara based combination therapy. The gene discussed is CD38; the disease is Miyoshi myopathy.