CD274 and Miyoshi myopathy: Several studies have demonstrated that MM cell (either cell lines or primary cells) upregulate PD‐L1, and its receptor PD‐1 is found on a proportion of T cells.13, 14, 15, 16 Moreover, dendritic cells (DC) in MM bone marrow expressed PD‐L1 and induced a suppression of PD‐1‐expressing T‐cell and NK‐cell immune functions by engaging immune checkpoints via the PD‐L1/PD‐1 signaling axis.17 Herein, we aimed to assess the immunomodulatory effects of Dara on CD38 expressing immune cells in the blood of newly diagnosed MM patients receiving Dara based combination therapy.