The oxidative metabolism appeared severely compromised in DMD as Pyruvate dehydrogenase E1 component subunit alpha, somatic form (PDHA1), Aconitate hydratase (ACO2), 2‐oxoglutarate dehydrogenase (OGDH), and mitochondrial Malate dehydrogenase (MDH2) decreased in DMD compared with BMD and controls. The gene discussed is ACO2; the disease is Duchenne muscular dystrophy.