Duchenne muscular dystrophy patients were characterized by an increment of extracellular matrix (ECM) proteins such as Asporin (ASPN), Biglycan (BGN), Cadherin‐13 (CDH13), Collagen alpha‐1(I), alpha‐2(I), and alpha‐1(II) chain (COL1A1, COL1A2, and COL2A1), Decorin (DCN), Fibrillin‐1 (FBN1), Galectin‐1 (LGALS1), Lumican (LUM), Mimecan (OGN), and Prolargin (PRELP). This evidence concerns the gene LGALS1 and Duchenne muscular dystrophy.