The consequence of CXCL12 with its receptor CXCR4 or CXCR7 has become one of the hotspots in the study of the development of various malignant tumours.9 One of the important roles of CXCL12‐CXCR4/CXCR7 is to regulate the adhesion, metastasis, colonization, angiogenesis and proliferation of tumour cells to endothelial cells.10 Given the biological behaviour of trophoblasts similar to cancer cells, it has been indicated that CXCL12 and its receptors also mediated trophoblasts differentiation, invasion, and proliferation. The gene discussed is CXCL12; the disease is neoplasm.