HS3ST4 and cancer: Interestingly, some peaks correspond to TRF2‐bound ITSs (interstitial telomeric sequences) previously characterized in cancer cell lines, such as a binding site at the intron of the HS3ST4 gene (Simonet et al., 2011; Yang et al., 2011), whose expression is regulated by TRF2 (Biroccio et al., 2013).