In fact, additive or synergistic effects of an M1R PAM and an AChEI have been shown in behavioral paradigms and on M1R downstream signaling.21, 27, 44 Importantly, contrary to the low cooperative M1R PAM TAK‐071, the combination of T‐662, an M1R PAM with high cooperativity, and donepezil did not produce any additive or synergistic effects against scopolamine‐induced cognitive deficits.27 The gene discussed is CHRM1; the disease is Cognitive impairment.