KRAS and familial pancreatic carcinoma: By contrast, colorectal cancers frequently harbor KRAS mutations, which are rare in melanomas (AACR Project GENIE Consortium, 2017) but extremely frequent in pancreatic cancers (Lanfredini et al., 2019). A thorough analysis of the mutanome of >60,000 tumors has demonstrated, however, that tumors have remarkably few shared alterations with other tumors, even in the context of major driver alterations and in specific disease types (Hartmaier et al., 2017).