VEGFA and neoplasm: Given their dependency on specific genetic events, GEMM have proved to be useful for testing the efficacy of agents targeting farnesyl transferase, epidermal growth factor receptor, angiogenesis, matrix metalloproteases and vascular endothelial growth factor (VEGF) to inhibit tumor growth (Van Dyke and Jacks, 2002; Suggitt and Bibby, 2005; Kohl et al., 1995; Lenferink et al., 2000; Bergers et al., 1999; Bergers et al., 2000; Huss et al., 2003).