GDF15 and colorectal neoplasm: Codonopsis pilosula component inhibited the cancer cell proliferation and migration.10 It was proposed that C pilosula restrained hepatocellular carcinoma via GDF15 and HMOX1.11 Lobetyolin also presented cytotoxic activity against lung cancer.12 Although there was limited literature focused on the pharmacological effect of Lobetyolin on colon cancer, we assumed that Lobetyolin might function as a therapeutic candidate for colorectal tumour.