Previous investigators illuminated that the prevention of glutamine uptake could induce the apoptosis of glutamine addicted tumours.18 ASCT2 drives glutamine transport through nutrient transporters in diverse cancers.19 The silence of ASCT2 repressed intracellular glutamine accumulation and contributed to apoptotic cell death in human breast cancer.20 The experimental data revealed that the inhibition of ASCT2 by Benser successfully reduced the levels of glutamine metabolism indices including Glutamine, glutamic acid, α‐ketoglutarate, ATP and GSH. This evidence concerns the gene SLC1A5 and cancer.