ASCT2 functioned as the significant prognostic and preventive factor in tongue cancer through p53.23 It was proposed that glutaminase was a p53 target gene for tumour suppression.13 The expressions of p21 and p53 were altered in glutamine‐deficient hepatoma cells.24 To explore the underlying p53 dependence of Lobetyolin‐mediated glutamine metabolism in colon cancer cells, Pifithrin‐α, the selective inhibitor of p53, was exposed to HCT‐116 cells. The gene discussed is TP53; the disease is tongue cancer.