TR was estimated using objective tumor measurements which are measured using imaging methods and determined according to the Response Evaluation Criteria in Solid Tumors guidelines28 or the World Health Organization recommendations.29 The RCTs in the systematic review contain five treatment classes: the class of chemotherapies, the anti‐epidermal growth factor receptor (Anti‐EGFR) monoclonal antibodies class, angiogenesis inhibitors, other molecular‐targeted agents and intrahepatic arterial chemotherapies . Here, EGFR is linked to neoplasm.