In addition, these interacted genes of E2F8 also related with many types of human malignancies including bladder cancer, non-small cell lung cancer, glioma, pancreatic cancer, melanoma, chronic myeloid leukemia, small cell lung cancer and prostate cancer (Figure 6D). The gene discussed is E2F8; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.