Heatmap of E2F8 expression in HCC tumors was also presented in Figure 5A. As shown in Figure 5B, E2F8 mRNA was significantly higher in HCC patients with advanced neoplasm grade, AJCC stage and α-fetoprotein elevation (all P < 0.05, Figure 5B). The gene discussed is E2F8; the disease is hepatocellular carcinoma.