As shown in Figure 3, E2F8 high expression was significantly correlated with poor OS (HR = 1.99, 95%CI = 1.4–2.84, P = 1E-04, Figure 3A), and same trends were observed when comparing 1-, 3- and 5-year OS in HCC patients (HR = 3.34, P = 3.3E-05; HR = 2.74, P = 1E-06 and HR = 2.14, P = 4.1E-05, respectively, Figure 3B–D). Here, E2F8 is linked to hepatocellular carcinoma.