Moreover, up-regulation of E2F8 was significantly associated with DSS, 1-, 3- and 5-year DSS in HCC patients (HR = 2.76, P = 1.3E-05; HR = 7.49, P = 0.00013; HR = 5.29, P = 2.4E-08 and HR = 2.92, P = 1.1E-05, respectively, Figure 4A–D). Here, E2F8 is linked to hepatocellular carcinoma.