E2F8 and hepatocellular carcinoma: HCC patients with high E2F8 levels had poor PFS, 1-, 3- and 5-year PFS compared with those in E2F8 low expression group (HR = 1.93, P = 1E-05; HR = 2.62, P = 5.7E-07; HR = 2.01, P = 8.4E-06 and HR = 1.92, P = 1.3E-05, respectively, Figure 4E–H).