After adjusting tumor status, AJCC stage and new tumor event after initial treatment in multivariate Cox regression model, high level of E2F8 showed to be an independent risk factor for OS in HCC patients (HR = 2.16, 95%CI = 1.3–3.59, P = 0.003, Table 2). The gene discussed is E2F8; the disease is hepatocellular carcinoma.