As discussed above, this mechanism is likely to function in many animal species. In other species, forces may be generated by means other than Arp2/3-mediated actin polymerization, but the segregation of nuclear membranes from the lamin network appears to be a general feature of nuclear rupture observed in dividing mammalian somatic cells, as well as during the interphase NE rupture that is frequent in cancer cells. This evidence concerns the gene LMNA and cancer.