ZEB2 and Hirschsprung disease: Haploinsufficiency of ZEB2 causes Mowat‒Wilson syndrome [MWS, OMIM 235730], a syndrome characterized by intellectual disability, delayed motor development, epilepsy, microcephaly, characteristic facial features, heart defects, genitourinary malformations, and Hirschsprung disease (Kluk et al., 2011; Mowat et al., 1998; Mowat, Wilson, & Goossens, 2003).