Other studies have found that the regulation of autophagy through the expression of ATG12 increases the sensitivity of cancer to therapeutics,42, 43 and the inhibition of autophagy can significantly enhance the results of combination therapy.44 Sun et al43 found that autophagy was associated with increased sensitivity to epirubicin (EPI) and that the expression of autophagy/Beclin 1 regulator 1 (Ambra1) was negatively correlated with EPI sensitivity in breast cancer cells. This evidence concerns the gene ATG12 and cancer.