PTBP3 and pancreatic neoplasm: An association between hypoxia‐induced chemoresistance and autophagy is becoming increasingly apparent.34, 35, 36 Moreover, hypoxia‐associated genes and autophagy are implicated with a less favourable outcome in PDAC.37, 38 PTBs are known to regulate gene expression by binding to hypoxia‐related transcripts 20; therefore, we also studied the role of PTBP3 in the development of PDAC and therapeutic resistance in tumour tissue and in pancreatic cancer cell lines under hypoxic stress.