There has only been one study showing that MIR100HG could form a double‐negative feedback loop with GATA6 and activate the Wnt/β‐catenin pathway, causing cetuximab resistance in colon cancer cells.41 As for MIR31HG, Eide et al found that MIR31HG was an independent prognostic factor for patients with colon cancer.42 Meanwhile, the cell lines with high MIR31HG outlier expression were characterized by an elevated EMT signature and TGFβ signalling activation.42 This result is consistent with our findings. Here, TGFB1 is linked to malignant colon neoplasm.