In colon cancer, down‐regulation of lncRNA MEG3 promotes cancer cell proliferation and migration via upregulating clusterin,39TGF‐β1 and SPHK1.40 MIR100HG is a kind of microRNA host gene, the intron of which encodes three kinds of microRNA, including miR‐100, miR‐125b‐1 and let‐7a‐2. The gene discussed is MEG3; the disease is malignant colon neoplasm.