Present study reports that AMPK is activated to respond the oxidative stress in cancer cells and neurons.9, 10 Meanwhile, it is reported that AMPK can increase the nuclear accumulation of Nrf2 though activating phosphorylation of GSK3β.11 GSK3β is a key enzyme in glucose metabolism, and the participation of it in cell regulation has been proven. The gene discussed is PRKAB1; the disease is cancer.