ANXA8 and major depressive disorder: Among the 10 genes correlating highly with the BPND of the 5-HT1AR in both cortical and subcortical regions were Anxa8 and BDNF. BDNF has been repeatedly connected to psychiatric disorders such as schizophrenia, bipolar disorder, depression, and addiction (Autry and Monteggia 2012) and the action of psychopharmacologic drugs.