The effect of HMGB‐1 is potentiated via the P‐selectin–PSGL‐1 axis,128 with P‐selectin–deficient mice being protected against DVT.46, 129, 130 In addition to promoting NETosis, platelet‐originated HMGB‐1 also increases neutrophil and monocyte sequestration at the venous wall, increasing local inflammation. The gene discussed is SELP; the disease is deep vein thrombosis.