Chen et al. (2012) found that the expression of PD-L1 in HCC is related to the inflammatory microenvironment in which macrophages participate. We found that the prognosis signature of ATGs is positively correlated with macrophage infiltration and PD-L1 expression. Thus, the autophagy process affects HCC macrophage infiltration, and the prognosis signature of ATGs can predict the PD-L1 therapeutic effect. And studies show that the combination of autophagy blocker and PD-L1 inhibitor has a significant anti-tumor effect compared with PD-L1 inhibitor alone (Robainas et al., 2017). This evidence concerns the gene CD274 and neoplasm.