SNCA and synucleinopathy: Thus, outside of the great improvement in the usage of a seed derived from a source other than CSF (which dramatically improves the well-being of a patient, compared to the painful procedure of the lumbar puncture), they also produced evidences of a difference in the seeding activity of PD derived α-synuclein compared to MSA derived α-synuclein, indicating a putative strain difference between both pathologies, in line with previous studies reporting putative strain differences among synucleinopathies [113–115].