Aggregated α-synuclein can be transmitted from neuron to neuron [26] either after neuronal death or by exocytosis-mediated pathways [26], while the uptake may occur be endocytic pathways [27], substantiating the neuron-to-neuron transmission and the predictable spreading observed in some forms of α-synucleinopathies. This evidence concerns the gene SNCA and synucleinopathy.