To date, increasing evidence has shown that ubiquitin E3 ligase and deubiquitination enzymes are directly involved in the regulation of tumor formation and metastasis of lung cancer, especially through the RAS-RAF-MEK-ERK and PI3K-AKT-mTOR signaling pathways, in which the ubiquitination of key signal nodes determines the biological and biochemical processes of tumor cells (Table 1). This evidence concerns the gene PIK3CA and lung carcinoma.