EGFR and non-small cell lung carcinoma: In addition, the functional defects of EGFR with specific mutations (L858R, del746–750 or L858R + T790 M) in NSCLC cells can be impaired, probably due to a propensity of the mutants to heterodimerize with HER2, thereby evading c-Cbl-mediated ubiquitination and subsequent sorting to degradation in lysosomes [108].