Intriguingly, the E3 ligase CHIP could selectively interact with and degrade the EGFR mutants such as G719S, L747_E749del A750P or L858R and inhibited tumor cell proliferation and xenograft growth of EGFR mutant but not EGFR WT cell lines, which might provide novel therapeutic strategies for overcoming the EGFR-TKI resistance in lung adenocarcinoma [109]. Here, EGFR is linked to lung adenocarcinoma.