In lung cancer disease, the sustained activation of ERK is a common event and frequently contributes the tumor growth and even the metastatic processes; therefore it might be an efficient way to abolish the enhanced Ras protein level or Ras-GTP activity by inhibiting its E3 ubiquitin ligase (i.e. NEDD4–1) to suppress the tumor progress. This evidence concerns the gene NEDD4 and neoplasm.