BMI1 and neoplasm: Analytical imaging of NODSCID mice with orthotopically implanted luciferase-tagged mGIC revealed that while 5/9 mice injected with control mGIC developed tumours and silencing of Bmi1 strongly suppressed tumour growth (0/9), concomitant silencing of EfnA5 and Bmi1 rescued tumour incidence (6/9) (Fig. 6a, b).