Our data showing that circHomer1a, but not linear HOMER1 mRNA, is altered in the PFC and stem cell-derived neuronal cultures of subjects with SCZ and BD, is associated with the age of onset of SCZ, and could influence the abundance of numerous mRNA isoforms known to regulate synaptic transmission, introduce a novel potential upstream regulator of neuronal function within the PFC stemming from the HOMER1 gene. The gene discussed is HOMER1; the disease is Behcet disease.