To determine the relative HOMER1 mRNA changes in BD and SCZ, we measured the expression of total HOMER1 mRNA in linear RNA-enriched cDNA samples following oligo-dT reverse transcription with specific primers designed to avoid circRNA detection, and after normalization to 18S rRNA (a reliable normalizer unchanged in BD and SCZ; Supplementary Fig. 3b, c) [10, 54, 55]. This evidence concerns the gene HOMER1 and Behcet disease.