PTEN and cancer: Further, we found that proteins that are involved in the KEGG Cancer Pathways were dysregulated in both the subtype-1 and subtype-2 tumours; these pathways encompass several known oncoproteins (such as RAD51, BRAC1, and ERBB2) and tumour suppressor proteins (such as PTEN and CDK2A1)28–30 (Fig. 2C).