MTOR and neoplasm: Specifically, whereas subtype-1 tumours show upregulation of mTOR signalling associated kinases (among others, MTOR-pS2448, GSKB-pS21-S9, and PDK-pS241), subtype-2 tumours display upregulation of cell cycle associated kinases (among others, CDK1-pY15, p27-pT158, and p27-pT198; Fig. 3E).