A recent meta-analysis of 65 randomized controlled trials (including 25 994 cancer patients treated with cetuximab, panitumumab or nimotuzumab) indicated that the use of anti-EGF-R mAbs significantly increases the risk of developing skin toxicity (rash, hand–foot syndrome, dry skin and oral mucositis), but patients receiving nimotuzumab have the lowest risk among all6. Here, EGFR is linked to neoplasm.