EGFR and dermatological toxicity: A recent meta-analysis of 65 randomized controlled trials (including 25 994 cancer patients treated with cetuximab, panitumumab or nimotuzumab) indicated that the use of anti-EGF-R mAbs significantly increases the risk of developing skin toxicity (rash, hand–foot syndrome, dry skin and oral mucositis), but patients receiving nimotuzumab have the lowest risk among all6.