Based on the PediCan database29, we defined different lists of pediatric cancer genes (pedCGs) implicated in ALL (113 genes), AML (32 genes), WT (49 genes), MBL (113 genes), NBL (166 genes) and glioma (22 genes) (Additional File 1: Table S2). The gene discussed is NUMBL; the disease is acute lymphoblastic leukemia.