In melanoma, the induced MCL-1 dependence described in the current studies adds to other reports describing, for example, RTK-mediated RAF-MEK-ERK reactivation11 and MITF-driven changes in tumor cell metabolism12 as mechanisms of adaptive survival, and it also complements recent studies identifying sensitivity to GPX4-mediated ferroptosis induction in cells surviving targeted therapy13,14. The gene discussed is MAP2K7; the disease is melanoma.