FOXO1 and embryonal rhabdomyosarcoma: ERMS is characterized by the loss of heterozygosity (LOH) at the 11p15 locus2 while ARMS is characterized by the chromosomal translocation t (2;13) (q35; q14) or t (1;13) (q36; q14), which generate chimeric PAX3-FOXO1 or PAX7-FOXO1 oncogenic fusion proteins3,4.