Comparison of the laBCC tumours before systemic treatment with localised BCC tumours yielded a significant differential expression of three genes of the Hh pathway: GAS1, GLI similar 2 (GLIS2), and protein kinase CAMP-activated catalytic subunit gamma (PRKACG) (P < 0.05; Table 2). This evidence concerns the gene PRKACG and skin basal cell carcinoma.