Immunohistochemistry analysis of H3K36me3 expression levels, used as a readout for SETD2 enzymatic activity, as well as ATG12 protein expression, confirmed low H3K36me3, but high ATG12 expression levels in most of the ccRCC tumors biopsies (Fig. 8b–e and Supplementary Fig. 6a–c). Here, ATG12 is linked to nonpapillary renal cell carcinoma.