Indeed, this experimental set revealed that in the CAKI-1 cells, i.e., SETD2-deficient RCC cells, exhibit a higher ATG12 expression level, and detection of immunoreactive bands, in addition to the one corresponding to the ATG5–ATG12 covalent complex, for free ATG12 protein, as well as for an additional ATG12-containing complex around 60 kDa. This evidence concerns the gene SETD2 and renal cell carcinoma.