On the other hand, overexpression of the wild-type or non-phosphorylatable cofilin mutant S3A increases cell invasion of melanoma cells and human glioblastoma cells, but inhibits the invasiveness of human lung cancer (H1299) cells by disrupting the actin cytoskeleton at the leading edge of the cell (Jang et al., 2012; Wang et al., 2007; Yamaguchi and Condeelis, 2007). Here, CFL1 is linked to melanoma.