Among these are retinitis pigmentosa 12 (RP12) and Leber congenital amaurosis (LCA), severe ocular dystrophies leading to PRC degeneration caused by mutations in CRUMBS1 (CRB1) or CRB2 (Chen et al., 2018; den Hollander et al., 1999; reviewed in Bujakowska et al., 2012; Slavotinek, 2016). This evidence concerns the gene CRB1 and Leber congenital amaurosis.