Among these are retinitis pigmentosa 12 (RP12) and Leber congenital amaurosis (LCA), severe ocular dystrophies leading to PRC degeneration caused by mutations in CRUMBS1 (CRB1) or CRB2 (Chen et al., 2018; den Hollander et al., 1999; reviewed in Bujakowska et al., 2012; Slavotinek, 2016). The gene discussed is CRB2; the disease is Leber congenital amaurosis.