The direct link between pancreatitis and autophagy-lysosomal pathway was illustrated by deletion of several essential Atg and lysosomal genes, which caused spontaneous pancreatitis.7, 8, 9, 10 Moreover, decreased pancreatic LAMP1/2 and lysosomal dysfunction have also been reported in human and mouse alcoholic pancreatitis.8 This evidence concerns the gene LAMP1 and pancreatitis.