TACC3 and glioblastoma: However, while in glioblastoma, the FGFR3-TACC3 fusion reportedly localizes to the mitotic spindle poles [35], we observed that the vast majority of FGFR3-TACC3 fusion and all of wildtype FGFR3 localized to the cytoplasm and plasma membrane, consistent with data from HeLa cells [38], the requirement for entry into the secretory pathway or localization to the plasma membrane for FGFR3-TACC3 oncogenic function [45] and coupling of FGFR3-TACC3 to canonical downstream signaling pathways usually activated at the plasma membrane.