Interestingly, several studies have pointed out a relationship between the decrease in serum soluble Klotho and worse outcomes in vascular functional tests, like reduced capacity of flow-mediated dilation of the brachial artery, or higher values of epicardial fat thickness and carotid artery intima-media thickness (cIMT) in healthy adults [8], or increased ankle-brachial pulse wave velocity, left ventricular mass index, cIMT and carotid atherosclerotic plaque quantity in chronic kidney disease population [5–7]. The gene discussed is KL; the disease is chronic kidney disease.