LGALS9 and systemic lupus erythematosus: As shown in Fig 5A, serum levels of Gal-9 were significantly higher in SLE patients with at least one organ damage (SDI ≥ 1) compared with those without organ involvement (23.1 ng/ml [IQR: 4.8–59.7] versus 12.5 ng/ml [IQR: 3.6–36.6], p = 0.013).