Levels of Gal-9 were significantly higher in the CSF from patients with recent-onset neuropsychiatric SLE (NPSLE) than in those from non-SLE controls (3.5 ng/ml, [IQR; 1.0–27.2] versus 1.2 ng/ml, [IQR; 0.9–2.1], p = 0.009). This evidence concerns the gene LGALS9 and systemic lupus erythematosus.