Interestingly, the levels of Tyr421 and Tyr466 (corresponding to Tyr421 and Tyr470 in human cortactin, respectively) were higher in metastatic sarcomatoid renal cell carcinoma (SRCC) patients compared to patients with non-metastatic carcinoma [62]; suggesting a direct role of this phosphorylation in tumour invasiveness. The gene discussed is CTTN; the disease is metastatic carcinoma.