NFKB1 and cancer: Overall the reported data support the concept that CXCL8 production in unstimulated GB cells, possibly linked to the aberrant activation of NF-κB [26, 30], results in a constitutive activation of the cognate receptors and the activation of key pathways involved in cytoskeletal rearrangement and cell mobilization, which may account for the invasive potential of these cancer cells.