Zhu et al. (2007) also demonstrated that phosphorylation of TOPK at Tyr74 and Tyr272 by https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2206&familyId=619&familyType=ENZYME increases the stability and activity of TOPK, thereby promoting colon cancer growth (Xiao et al., 2016). Here, PBK is linked to malignant colon neoplasm.