SPACDR and Globozoospermia: In addition to mutations in genes already linked to globozoospermia in mice, we identified variants in novel genes C2CD6 (c.338A > G; p.(His113Arg)), CCIN (c.853G > A; p.(Gly285Ser)) and C7orf61 ((c.259del; p.(Glu87Argfs*46)), with a clear link to acrosome biology.