Amongst other factors, hyper-transcription has been associated with Myc, a known collaborator of Kat2a in transcriptional regulation (Hirsch et al., 2015), which is broadly required in AML (Delgado and León, 2010), including in MLL fusion-driven disease (Schreiner et al., 2001). Here, KAT2A is linked to acute myeloid leukemia.