Also, separate inspection of the differentiation trajectories for Kat2a WT (Figure 4—figure supplement 2A–B) and Kat2a KO cells (Figure 4—figure supplement 2C–D) suggests that the almost linear developmental relationship between WT leukemia cells is replaced by multiple branching decisions upon Kat2a loss, an observation also captured by a second pseudo-time trajectory algorithm (Figure 4—figure supplement 2E–F). Here, KAT2A is linked to leukemia.