Despite the equivalent number of phenotypic LSC in the primary leukemias of both genotypes (Figure 2C), recipients of Kat2a KO leukemia cells failed to develop leukemia at the lowest cell doses and had a dramatically reduced frequency of functional LSC (Figure 4C–D), indicating that a requirement for Kat2a in leukemia self-renewal and/or propagation. Here, KAT2A is linked to leukemia.