KAT2A and leukemia: Secondary leukemias, like primary leukemias, did not have a reduction in surface phenotypic LSC (L-GMP, Figure 4E), putatively highlighting a dissociation between primitive surface phenotype and function, or highlighting the existence of multiple stem-like states, as suggested by cluster-specific depletion at the undifferentiated end of the Kat2a KO leukemia trajectory.