To this end, we pooled samples from 4 to 5 primary leukemias of each genotype, sorted live GFP+ cells reporting the presence of the MLL-AF9 fusion, and successfully sequenced over 4000 cells Kat2a WT and KO cells each, for a total of 13166 transcripts, using a high-throughput 10X Genomics platform (Zheng et al., 2017). Here, KMT2A is linked to leukemia.