We identified promoters as H3K4 tri-methyl (me3) peaks (Figure 5—figure supplement 1A) and enhancers with H3K4 mono-methyl (me1)- enriched regions (Figure 5—figure supplement 1B) and inspected the respective pattern of distribution of H3K9ac in pooled MLL-AF9 primary leukemias initiated by Kat2a KO or WT cells. This evidence concerns the gene KAT2A and leukemia.