We started by verifying that perturbed regulation by Kat2a had functional consequences for the translation machinery by performing polysomal profiling of MLL-AF9-carrying MOLM-13 AML cells in which KAT2A activity was inhibited by the MB-3 inhibitor (Tzelepis et al., 2016). The gene discussed is MLLT3; the disease is acute myeloid leukemia.