However, transcription factor depletion at promoters was not exclusive to Myc, and we made similar and indeed more extensive observations with another broad metabolic regulator, Gabpa, which has been previously characterized as a regulator of CML self-renewal (Yang et al., 2013; Yu et al., 2012) and associated with Kat2a-containing complexes (Krebs et al., 2011), but for which a requirement in AML has not been established. This evidence concerns the gene MYC and acute myeloid leukemia.