In order to investigate the impact of Kat2a loss on self-renewal vs. differentiation of AML stem-like cells (AML-SC), we generated an inducible conditional Kat2aFl/Fl KO mouse model and transformed Kat2a excised (KO) and non-excised (WT) bone marrow (BM) cells through retroviral delivery of an MLL-AF9 fusion transcript. Here, KMT2A is linked to acute myeloid leukemia.