Critically, we observed that binding of both TF at promoter regions dependent on Kat2a for H3K9ac was globally reduced in Kat2a KO leukemias (Figure 5E–F) as compared to WT (Myc: 95% CI WT-KO enrichment 0.01273 to 1.589; 2-way ANOVA p<0.05 for genotype contribution; Gabpa: 95% CI WT-KO enrichment 0.2640 to 1.364; 2-way ANOVA p<0.01 for genotype contribution), thus suggesting that Kat2a may regulate binding of sequence-specific TF at the promoter regions it acetylates. Here, MYC is linked to leukemia.