In addition, the DeepSEA framework failed to predict regulatory impact at loci where T2D causative variants have been established through multiple lines of evidence (such as at rs10830962 at MTNR1B (Gaulton et al., 2015) and rs7903146 at TCF7L2Gaulton et al., 2010), both of which were correctly identified as regulatory in our islet-based study. This evidence concerns the gene MTNR1B and type 2 diabetes mellitus.