To explore this further, we focused on a T2D-association signal at the PROX1 locus, identified after conditioning the T2D association on the primary (most significant) association signal at rs340874; on the basis of patterns of phenotypic association of the T2D-risk allele with continuous diabetes-related traits, this variant is associated with a primary effect on insulin secretion (Dimas et al., 2014). This evidence concerns the gene PROX1 and diabetes mellitus.