Both sporadic and familial EA cases have been associated with sarcomeric genes including myosin heavy chain 7 (MYH7) (Bettinelli et al., 2013; Postma et al., 2011) and filamin A (FLNA) (Mercer et al., 2017), transcription factor genes including NKX2.5 (Benson et al., 1999; Gioli‐Pereira et al., 2010) and GATA4 (Digilio et al., 2011), and channel genes such as sodium channel voltage gated type V (SCN5A) (Neu et al., 2010), all of which have a role in myocardial development (Sicko et al., 2016). Here, FLNA is linked to Esophageal atresia.