Phosphorylation levels of PI3K and AKT affect the proliferation, invasion, and apoptosis of cancer cells remarkably.14,22,24 Yang et al24 found that miRNA-122 suppresses the expression of TRIM29 and then blocks the activation of PI3K-AKT pathway, which results in the inhibition of the development of NPC. This evidence concerns the gene AKT1 and cancer.