In conclusion, this research revealed that BBOX1‐AS1 promoted CRC progression by sponging miR‐361‐3p and up‐regulating SH2B1, which suggested a BBOX1‐AS1/miR‐361‐3p/SH2B1 axis in CRC and provided a promising insight for CRC treatment. Here, BBOX1 is linked to colorectal carcinoma.