One‐way analysis of variance (ANOVA) was used to investigate if S‐MK correlates with disease progression, precise tumor stage, lymph node metastasis, distant metastasis, resection status, grading, UICC classification, tumor localization, CEA, and CA 19‐9. The gene discussed is CEACAM5; the disease is metastatic malignant neoplasm in the lymph nodes.