TNF and systemic lupus erythematosus: The supernatants of anti-RNP IgG treated SLE neutrophils induced the greatest release of IFNα and activated pDCs leading to the production of Tumor Necrosis Factor-α (TNFα), cytokine alterations -interleukin-6 (IL-6), and interferon-inducible protein-10 (IP-10).