CLOCK and intervertebral disk degenerative disorder: As the most recent research has shown, inflammation is a significant factor in IDD, as IL-1β abolishes the normal molecular functions of clock-related components, participates in multiple pathological processes during disc degeneration (including inflammatory responses, matrix destruction, angiogenesis and innervation, apoptosis, oxidative stress and cellular senescence), and activates protective autophagy in IVDs103.