Immunohistochemical analysis of TIGAR at various stages of PDAC tumorigenesis showed an increase in TIGAR expression during the early stages of tumor development in both the KFC mouse model (Figures 7A and 7B) and human PDAC samples (Figures 7C and 7D), consistent with a role for TIGAR in limiting ROS and promoting the survival of these preinvasive cells. This evidence concerns the gene TIGAR and neoplasm.